Compositions and processes for improved mass spectrometry analysis
AssigneeAgena Bioscience, Inc.
InventorThomas Becker
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Abstract
The invention provides a novel additive for improved analysis by mass spectrometry. More specifically, ascorbic acid has been found to reduce or eliminate the presence of adducts commonly present in mass spectra. The improved processes and compositions of the invention allow for increased accuracy, sensitivity and throughput for samples analyzed by mass spectrometry.
Claims21
A substrate for mass spectrometry, comprising target sites, wherein more than one of the target sites comprise a matrix material suitable for matrix-assisted laser desorption/ionization mass spectrometry and an adduct-reducing additive comprising ascorbic acid, or a salt, tautomer or analog thereof, wherein the molar ratio of the adduct-reducing additive to the matrix material is about 1:20, about 1:19, about 1:18, about 1:17, about 1:16, about 1:15, about 1:14, about 1:13 or about 1:12.
Dependencies are inferred from the claim text.