Oligonucleotides for SARS-CoV-2 modulation

A branched RNA oligonucleotide compound comprising:

• two or more RNA molecules each comprising 15 to 35 nucleotides in length, and wherein at least two of the RNA molecules each comprise a sequence that is perfectly complementary to at least 10 contiguous nucleotides of a 45 nucleotides target region sequence of SARS-CoV-2 selected from the group consisting of SEQ ID NOs:
• 127, 132, 202, and 222;
• wherein the two or more RNA molecules are connected to one another by one or more moieties independently selected from a linker, a spacer, a branching point, and a combination thereof.