TrkA antibody and application thereof
Assignee4B Technologies (Suzhou) Limited
InventorsXiaoming Guan, Chen Lv, Bai Lu, Gang Lu, Jun Zhou, Dong Yang, Jie Xie, Jing Su
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Abstract
The present disclosure provides TrkA antibodies, compositions comprising such antibodies, and methods of using such antibodies for the prevention and/or treatment of a disease or disorder associated with an inappropriate expression or function of TrkA, such as pain.
Claims14
An antibody or an antigen binding fragment thereof, which is capable of specifically binding to TrkA, the antibody or the antigen binding fragment thereof comprises a light chain CDR1, a light chain CDR2, a light chain CDR3, a heavy chain CDR1, a heavy chain CDR2 and a heavy chain CDR3, wherein:
- 1) the light chain CDR1-3 comprises the amino acid sequence as set forth in SEQ ID NOs:
- 28, 30, and 32 respectively, and the heavy chain CDR1-3 comprises the amino acid sequence as set forth in SEQ ID NOs:
- 20, 23, and 26 respectively, or
- 2) the light chain CDR1-3 comprises the amino acid sequence as set forth in SEQ ID NOs:
- 88, 30, and 32 respectively, and heavy chain CDR1-3 comprises the amino acid sequence as set forth in SEQ ID NOs:
- 20, 87, and 26 respectively.
Dependencies are inferred from the claim text.