Antibodies to L-type voltage gated channels and related methods
AssigneeThe University of British Columbia
InventorsWilfred Arthur Jefferies, Kyung Bok Choi, Shawna Rose Stanwood, Franz Fenninger, Brett Alexander Eyford, Lonna Munro, Cheryl Gurine Pfeifer, Reinhard Gabathuler
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Abstract
Provided are antibodies, and antigen-binding fragments thereof, which specifically bind to an extracellular poor loop of an alpha 1a subunit of L-type voltage gated calcium channel, and related compositions, kits, and methods of use thereof, for instance, administration to a subject in need thereof to modify an immune response, for example, in the treatment of cancer.
Claims1
An isolated antibody, or antigen-binding fragment thereof, which binds to an alpha I subunit of an L-type voltage-gated calcium channel, wherein the antibody or antigen-binding fragment thereof, specifically binds to an amino acid sequence of an extracellular domain selected from SEQ ID NO:2 and which comprises:
- a heavy chain variable region (VH) having the VH sequence of SEQ ID NO:37;
- and a light chain variable region (VL) having the VL sequence of SEQ ID NO:41, wherein (i) VH comprises VHCDR1 and VHCDR2 amino acid sequences of SEQ ID NOS:38-39;
- and (ii) VL comprises VLCDR1, VLCDR2 and VLCDR3 amino acid sequences of SEQ ID NO:
- 42, LAS, and SEQ ID NO:
- 44.
Dependencies are inferred from the claim text.