Crystalline form of antioxidant compound
AssigneeMitotech SA
InventorsMaxim Skulachev, Tatiana Zinevich, Olga Kirichenko, Anton Petrov, Vadim Tashlitsky
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Abstract
A novel crystalline form of 2,3-dimethyl-1,4-benzoquinone-5-decyl-triphenylphosphonium bromide is provided. The crystalline form was found to have X-ray powder diffraction peaks at 19.25, 21.507, and 23.074 degrees 2 theta, ±0.2 degrees 2 theta. Also provided are industrially feasible methods for manufacture of the crystalline form with high purity.
Claims20
A crystalline form of the compound 2,3-dimethyl-1,4-benzoquinone-5-decyl-triphenylphosphonium bromide.
A method for preparation of a crystalline form of the compound 2,3-dimethyl-1,4-benzoquinone-5-decyl-triphenylphosphonium bromide, the method comprising:
- (a) providing an alcoholic solution of 2,3-dimethyl-1,4-benzoquinone-5-decyl-triphenylphosphonium bromide;
- (b) adding a crystallization solvent to the alcoholic solution, wherein the crystallization solvent is selected from the group consisting of an ether and an ester;
- and
- (c) removing the alcohol and the crystallization solvent to obtain the crystalline form.
A composition comprising 2,3-dimethyl-1,4-benzoquinone-5-decyl-triphenylphosphonium bromide at a purity of greater than 98% by weight.
Dependencies are inferred from the claim text.