Back to results
US 12,077,514 B2Granted
Method for racemisation of (5R)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H¬isoxazol-3-yl]-2-methyl-benzoic acid
AssigneeIntervet Inc.
InventorHarald Schmitt
Life of this patent
Estimating the term…
Abstract
The present invention relates to a method for racemizing (5R)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-2-methyl-benzoic acid.
Claims8
A Method for racemizing a mixture containing (5R)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-2-methyl-benzoic acid according to Formula (1a) and (5S)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-2-methyl-benzoic acid according to Formula (1b)
- wherein the mixture has an enantiomeric excess of the compound according to Formula (1a) comprising the step of:
- (i) reacting the mixture with an alkaline compound in an organic solvent obtaining a reacted mixture
- wherein step (i) is carried out in the absence of phase transfer catalysts and wherein the organic solvent is 2 propanol and wherein the alkaline compound is potassium hydroxide, cesium hydroxide or potassium tert-butanolate.
Dependencies are inferred from the claim text.