US 12,076,464 B2Granted

Drug eluting shape memory foam

AssigneeThe Texas A&M University System

InventorsDuncan Maitland, Corey Bishop, Shreedevi Arun Kumar

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Abstract

Tumor resection is commonly practiced to prevent the progression of cancer. However, there are post-surgery concerns including the formation of a void that can allow cancer cells to escape at the surgery site, which increases the risk of metastasis. To counter this challenge, an embodiment includes a polyurethane-based shape memory foam as a tissue void-filling device that can also release anti-cancer drugs. Such foams may activate at body temperature and become malleable. Such properties may enable the foam to be shaped to precisely seal the tissue void and then serve as a drug-eluting device. Based on the drug composition with poly vinyl alcohol (PVA), the drug release profile from the foam may be altered depending on the application.

Claims21

Dependent claims

An apparatus comprising:

a shape memory polymer (SMP) foam including an open cell and additional open cells, the SMP foam having first and second states;
and
a material composition included in the open cell, the material composition including:
(a) a therapeutic agent, and (b) at least one of Polyvinyl alcohol (PVA), carboxymethyl cellulose, or combinations thereof;
wherein the therapeutic agent includes at least one of a drug, a peptide, a protein, an antigen, a nucleic acid, an anesthetic, an antihistamine, an antifungal agent, a vasodilator, an anti-inflammatory agent, an immunosuppressant, a growth factor, a cytokine, an interleukin, or combinations thereof
wherein:
(a) the SMP foam includes a reaction product of at least a first component and a second component, (b) the first component includes at least one of Hexamethylene diisocyanate (HDI), trimethyl hexamethylene diisocyanate (TMHDI), or combinations thereof, and (c) the second component includes at least one of Glycerol, 1,2,6-hexanetriol (HT), 3-methyl-1,5-pentanediol (MPD), 2-butyl-2-ethyl propanediol (BEP), or combinations thereof.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application: 17/072,166Filed 16 Oct 2020 · us provisional application
Priority: 17 Oct 2019
Published: US 2021/0113741 A122 Apr 2021
Granted: 3 Sep 2024
Term ends: Not estimatedThe source records don’t support an estimate.

Classification22 codes

A61L 27/56
Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface…:…
A61L 27/18
Macromolecular materials: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A61L 27/34
Materials for coating prostheses: macromolecular materials
A61L 27/54
Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface…:…