Compositions and methods for enhancing production, growth, spread, or oncolytic and immunotherapeutic efficacy of interferon-sensitive viruses
AssigneeOttawa Hospital Research Institute
InventorsJean-Simon Diallo, Mohammed Selman, Rozanne Arulanandam, Nicole Elise Forbes, Ramya Krishnan
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Abstract
Provided herein are fumaric and maleic acid-containing compounds, compositions comprising the same and methods for using such compounds to enhance production, growth, spread or titer of interferon-sensitive viruses in cells, particularly cancer and tumor cells. Also provided are methods of treating tumors or cancers in a subject by administering the compounds and compositions.
Claims18
A method of enhancing production, infection, growth, spread, or titer of an interferon-sensitive virus in an immortalized cell, a cancer cell or a tumor cell, the method comprising:
- administering a compound of Formula (I), or a pharmaceutically acceptable salt or solvate thereof,
- wherein R1 and R2 are each independently OH, (C1-2)alkoxy or linear, branched or cyclic, saturated or unsaturated (C3-20)alkoxy;
- said alkoxy is optionally substituted with one or more halogen, OH, (C1-4) alkyl, nitro or cyano;
- wherein when one of R1 and R2 is OH, the other of R1 and R2 is not OH,
- to the immortalized, cancer or tumor cell before, concurrently with, or after infection of the immortalized, cancer or tumor cell with the interferon-sensitive virus.
A method for treating a tumor or cancer in a subject in need thereof, which comprises administering a compound of Formula (I), or a pharmaceutically acceptable salt or solvate thereof,
- wherein R1 and R2 are each independently OH, (C1-2)alkoxy or linear, branched or cyclic, saturated or unsaturated (C3-20)alkoxy;
- said alkoxy is optionally substituted with one or more halogen, OH, (C1-4) alkyl, nitro or cyano;
- wherein when one of R1 and R2 is OH, the other of R1 and R2 is not OH, to the subject before, after, or concurrently with administering an interferon-sensitive oncolytic virus to the subject.
Dependencies are inferred from the claim text.