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US 12,076,301 B2Granted
Engaging the cervical spinal cord circuitry to re-enable volitional control of hand function in tetraplegic subjects
AssigneeThe Regents of the University of California
InventorsDaniel C. Lu, V. Reggie Edgerton, Roland R. Roy, Yury P. Gerasimenko
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Abstract
In various embodiments, methods are provided for applying transcutaneous and/or epidural spinal cord stimulation with and without selective pharmaceuticals to restore voluntary control of hand function in tetraplegic subjects.
Claims20
An electrical stimulation system, comprising:
- a pulse generator configured to neuromodulate the cervical spinal cord of a patient by providing an electrical signal to at least one surface stimulation electrode attached to a dorsal aspect of the neck of the patient;
- and
- wherein at least one of an amplitude and a frequency of the electrical signal are selected to improve, when the electrical signal is provided to the at least one surface stimulation electrode, at least one of voluntary motor control or grip strength of a hand of the patient.
An electrical stimulation system, comprising:
- a pulse generator configured to neuromodulate the cervical spinal cord of a patient by providing an electrical signal to at least one implanted stimulation electrode positioned to provide stimulation to at least a portion of the cervical spinal cord of the patient;
- and
- wherein at least one of an amplitude and a frequency of the electrical signal are selected to improve, when the electrical signal is provided to the at least one implanted stimulation electrode, at least one of voluntary motor control or grip strength of a hand of the patient.
A neuromodulation method, comprising:
- providing an electrical signal to at least one electrode, the at least one electrode positioned to provide cervical stimulation to a patient;
- measuring at least one of a maximum of a grip force of a hand of the patient, accuracy in controlling the grip force of the hand of the patient, or response time in changing the grip force of the hand of the patient;
- and
- configuring a stimulator to provide an updated electrical signal to the at least one electrode, the updated electrical signal based on the measured at least one of the maximum of the grip force, the accuracy in controlling the grip force, or the response time in changing the grip force.
1 more element
Dependencies are inferred from the claim text.