Pharmaceutical peptides for the treatment of inflammatory diseases
AssigneeProtagonists Ltd.
InventorsChai Ezerzer, Nicholas Harris
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Abstract
The invention provides pharmaceutical compositions comprising at least a portion of a chemokine receptor or a G-protein coupled receptor. The pharmaceutical composition of the invention may be used for altering immune system functioning, for example, to treat an immune system disorder, such as an autoimmune disease, multiple sclerosis, transplant rejection, psoriasis, rheumatoid arthritis and asthma. The invention also provides peptides that may be used individually, in combination with, or in combination with other therapeutic agents such as steroid, non-steroid anti-inflammatory drug, immune modulator or immune suppressor.
Claims7
A CKRD peptide selected from the group consisting of:
- (a) a peptide consisting of the amino acid sequence of SEQ ID NO:
- 16, and (b) a peptide consisting of the amino acid sequence of SEQ ID NO:
- 16;
- wherein amino acid positions 5, 6, and 7 of SEQ ID NO. 16 have been replaced with His-Gly-Met or Asn-Ala-Met;
- and
- wherein the peptide of (a) or (b) binds to cytokines MIG, I-309, Eotaxin, Eotaxin 2, Eotaxin 3, SDF1-α, SDF1-β, and MIP3-α, and has an anti-inflammatory effect.
Dependencies are inferred from the claim text.