Antisense oligonucleotide targeting ARL4C molecule, and nucleic acid drug using antisense oligonucleotide

An antisense oligonucleotide targeting ARL4C, consisting of a base sequence of:

• (i) a sequence represented by SEQ ID NO:
• 1, or
• (ii) a sequence consisting of the sequence represented by SEQ ID NO:
• 1 and 1-35 additional bases that are not represented by SEQ ID NO:
• 1 but that are adjacent to the 5′ and/or the 3′ side of the sequence of SEQ ID NO:
• 1 in the sequence complementary to the sequence of SEQ ID NO:
• 3, wherein the number of bases of the antisense oligonucleotide is from 16 to 50,
• wherein the antisense oligonucleotides of (i) and (ii) have at least one chemically modified nucleotide shown in (1) to (3):
• (1) a nucleotide having a substituent in the base moiety, wherein the substituent is a linear alkyl group having 1 to 6 carbon atoms, a linear alkoxy group having 1 to 6 carbon atoms, a mercapto group, a linear alkylthio group having 1 to 6 carbon atoms, an amino group, a linear alkylamino group having 1 to 6 carbon atoms, or a halogen atom,
• (2) a nucleotide having a chemically modified sugar moiety, wherein the nucleotide is a 2′,4′-bridged nucleotide or a nucleotide in which the hydroxyl group at the 2′ position of the sugar moiety is substituted with an alkoxy group or with a halogen atom,
• (3) a nucleotide having a chemically modified internucleoside bond, wherein the chemically modified internucleoside bond is least one member selected form the group consisting of phosphorothioate, chiral phosphorothioate, phosphorodithioate, phosphotriester, aminoalkylphosphotriester, 3′-alkylene phosphonate, 5′-alkylene phosphonate, phosphinate, 3′-aminophosphoramidate, aminoalkylphosphoramidate, thionophosphoramidate, thionoalkylphosphonate, thionoalkylphosphotriester, selenophosphate, and boranophosphate.