Blood processing apparatus and method for detoxifying bacterial lipopolysaccharide in vivo

A blood treatment method, comprising:

• inducing flow of blood of a human or animal patient through a blood treatment device inlet and outlet;
• and
• detoxifying at least one biological agent contained within the blood by passing the blood over at least one bioreactor surface having attached a phosphatase enzyme and/or an acyloxyacyl hydrolase (AOAH) enzyme, with the at least one bioreactor surface being contained within the blood treatment device and wherein the at least one biological agent is selected from the group consisting of:
• Gram negative bacterial lipopolysaccharide (LPS);
• Gram negative bacterial flagellin;
• Gram positive bacterial lipoteichoic acid;
• Gram positive bacterial flagellin;
• one or more bacterial extracellular nucleoside triphosphates including adenosine triphosphate (ATP), nucleoside diphosphates including adenosine diphosphate (ADP), and nucleotides including deoxyribonucleic acid (DNA) and ribonucleic acid (RNA);
• one or more yeast extracellular nucleoside triphosphates including ATP, nucleoside diphosphates including ADP, and nucleotides including DNA and RNA;
• one or more fungal extracellular nucleoside triphosphates including ATP, nucleoside diphosphates including ADP, and nucleotides including DNA and RNA;
• one or more viral extracellular nucleotides including DNA and RNA;
• and
• one or more host extracellular nucleoside triphosphates including ATP, nucleoside diphosphates including ADP, and nucleotides including DNA and RNA, and combinations thereof, wherein the blood treatment device includes a bioreactor associated with the bioreactor surface, and wherein the bioreactor comprises at least one of one or more surfaces of a hollow fiber bundle in a stent.