Blood processing apparatus and method for destroying cancer metastasis in vivo

A blood treatment method, comprising:

• inducing flow of blood of a human or animal patient through a blood treatment device inlet and outlet to a circulatory system of the patient;
• destroying one or more metastatic agents contained within the blood of the patient by continuously passing the blood of the patient over a bioreactor surface having an attached deoxyribonuclease 1 (DNase 1) enzyme, with the at least one bioreactor surface being contained within the blood treatment device;
• and
• returning the blood of the patient to the patient for continuous treatment until the metastatic agents have been reduced to predetermined levels, wherein the DNase 1 enzyme comprises human DNase 1 from human blood or tissues or synthetic human DNase 1 from recombinant deoxyribonucleic acid (DNA) technology;
• wherein the DNase 1 enzyme is immobilized and is used prophylactically or therapeutically to increase an effective concentration of DNase 1 in a bloodstream of the patient, and remove one or more nucleic acids within a biological system associated with the patient;
• wherein the nucleic acids include one or more nucleic acids produced by cancer cells in humans and animals;
• wherein the destroying prevents metastasis of tumor cells and metastatic DNA included in the metastatic agents, including circulating DNA (cirDNA) and neutrophil extracellular trap DNA (NET-DNA) in the bloodstream, by passage of the blood of the patient through the blood treatment device and over the bioreactor surface, without adding any chemicals to the blood of the patient;
• wherein the blood treatment device consists of a bioreactor associated with the bioreactor surface;
• and
• wherein the bioreactor comprises at least one of one or more surfaces of a hollow fiber bundle in a stent.