Optimized solid substrates, tools for use with same and uses thereof for promoting cell and tissue growth
AssigneeCartiheal (2009) Ltd.
InventorsNir Altschuler, Amir Goren
Life of this patent
Estimating the term…
Abstract
This invention provides optimized solid substrates for promoting cell or tissue growth or restored function, which solid substrate comprises aragonite and is characterized by a specific fluid uptake capacity value of at least 75%, or a contact angle value of less than 60 degrees when in contact with a fluid and which is further characterized by tapered sides and tools for implantation of optimized solid substrates.
Claims39
A method for treating a defect, disorder or disease in a subject in need,
- wherein the defect, disorder or disease is one of cartilage, bone, or a combination thereof;
- and
- wherein the method comprises implanting into said subject a solid substrate for promoting cell or tissue growth or restored function, wherein the solid substrate comprises a coral or coral derivative wherein the solid substrate is characterized by a specific fluid uptake capacity value of at least 75% or is characterized by having a contact angle value of less than 60 degrees, when in contact with a fluid, and is further characterized by
- at least one substantially flat cross section at a terminus of said solid substrate;
- a conical or pyramidal frustum shape;
- and
- tapered sides at an angle of from about 0.75 to about 4 degrees from a longitudinal axis along said solid substrate.
A method for treating a defect, disorder or disease in a subject in need,
- wherein the defect, disorder or disease is selected from a cartilage or osteochondral defect in the knee;
- and
- wherein the method comprises implanting into said subject a solid substrate for promoting cell or tissue growth or restored function, wherein the solid substrate comprises a coral or coral derivative, wherein the solid substrate is characterized by a specific fluid uptake capacity value of at least 75% or is characterized by having a contact angle value of less than 60 degrees, when in contact with a fluid,
- and is further characterized by
- at least one substantially flat cross section at a terminus of said solid substrate;
- a conical or pyramidal frustum shape;
- and
- tapered sides at an angle of from about 0.75 to about 4 degrees from a longitudinal axis along said solid substrate.
A method for treating a defect, disorder or disease in a subject in need,
- wherein the defect, disorder or disease is selected from osteoarthritis of the ankle or great toe;
- and
- wherein the method comprises implanting into said subject a solid substrate for promoting cell or tissue growth or restored function, wherein the solid substrate comprises a coral or coral derivative, wherein the solid substrate is characterized by a specific fluid uptake capacity value of at least 75% or is characterized by having a contact angle value of less than 60 degrees, when in contact with a fluid,
- and is further characterized by
- at least one substantially flat cross section at a terminus of said solid substrate;
- a conical or pyramidal frustum shape;
- and
- tapered sides at an angle of from about 0.75 to about 4 degrees from a longitudinal axis along said solid substrate.
A method for treating a defect, disorder or disease in a subject in need,
- wherein the defect, disorder or disease is costochondritis dissecans;
- and
- wherein the method comprises implanting into said subject a solid substrate for promoting cell or tissue growth or restored function, wherein the solid substrate comprises a coral or coral derivative, wherein the solid substrate is characterized by a specific fluid uptake capacity value of at least 75% or is characterized by having a contact angle value of less than 60 degrees, when in contact with a fluid,
- and is further characterized by
- at least one substantially flat cross section at a terminus of said solid substrate;
- a conical or pyramidal frustum shape;
- and
- tapered sides at an angle of from about 0.75 to about 4 degrees from a longitudinal axis along said solid substrate.
Dependencies are inferred from the claim text.