Methods and compositions for natural killer cells
AssigneeUniversity of Central Florida Research Foundation, Inc.
InventorsAlicja J. Copik, Jeremiah L. Oyer, Robert Y. Igarashi, Deborah Altomare
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Abstract
Disclosed herein are novel compositions and methods for stimulation of and the production or expansion of natural killer (NK) cells. Numbers of NK cells can be increased following contact with exosomes modified with one or more stimulatory peptides. Methods and compositions for the production of exosomes, wherein the exosomes comprises stimulatory peptides are also described. Also described are methods of treating cancer using the disclosed NK-stimulating exosomes or NK cells stimulated by the disclosed methods.
Claims12
A method for increasing the number of NK cells, comprising, contacting at least one NK cell with at least one NK-stimulating exosome comprising one or more stimulatory peptides present in an exosome membrane, wherein the exosome is an extracellular product of an engineered exosomal secretory K562 cell line, wherein one or more stimulatory peptides comprise IL-21.
Dependencies are inferred from the claim text.