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US 12,070,473 B2Granted
Cancer-killing cells
AssigneeLIfT BioSciences Ltd
InventorsAlex Blyth, Nico Bruyniks
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Abstract
The present invention relates to an in vitro culture of haematopoietic cells, wherein the haematopoietic cells differentiate to form granulocytes characterised by the ability to kill cancer cells. The invention also relates to the granulocytes, methods for identifying the haematopoietic cells and granulocytes, compositions and kits comprising the same, as well as uses of the same for treating cancer.
Claims13
A method for treating a cancer comprising:
- administering to a subject in need thereof a therapeutically effective amount of a composition comprising neutrophils derived from haematopoietic stem cells obtainable by a method, said method comprising:
- a. admixing granulocytes obtained from a donor with cancer cells from a cancer cell line to form an admixture;
- b. incubating said admixture;
- c. measuring a percent (%) of cancer cells killed in the incubated admixture;
- d. obtaining haematopoietic stem cells from a sample from the donor when the granulocytes kill at least 5% of the cancer cells in the incubated admixture;
- and
- e. differentiating the haematopoietic stem cells from the donor to obtain the composition comprising neutrophils;
- wherein the donor is allogeneic with the subject.
5 more elements
Dependencies are inferred from the claim text.