Topoisomerase inhibitor for mimicking the effect of ionizing radiations on T cells

An in vitro method for mimicking the effect of an ionizing radiation on T cells, comprising contacting said T cells with at least one inhibitor of topoisomerase, wherein the T cells are contacted with at least one inhibitor of topoisomerase for at least 50 hours, wherein the method mimics the effect of an ionizing radiation at a dose ranging from 2 Gy to 10 Gy, and wherein the effect is the percentage of T cells apoptosis measured 48 hours after ionizing radiation.