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US 12,065,692 B2Granted
Optical super-multiplexing by polyynes
AssigneeThe Trustees of Columbia University in the City of New York
InventorsWei Min, Fanghao Hu
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Abstract
A method for optical super-multiplexing using polyynes to provide enhanced images from stimulated Raman microscopy is disclosed. In some exemplary embodiments, the polyynes are organelle-targeted or spectral barcoded. Imaging can be enhanced by using the polyynes to image whole live cells or specific organelles within live cells. The polyynes can also be used in optical data storage (i.e., encoding) and identification (i.e., decoding) applications.
Claims12
A library comprising between 2 and about 200 polyynes, comprising polyynes having structures chosen from the following formulae:
- wherein each polyyne of the library is isotope enriched at the atoms specified and optionally conjugated to a solid support.
Dependencies are inferred from the claim text.