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US 12,065,677 B2Granted
Method for the fermentative production of guanidinoacetic acid
AssigneeEvonik Operations GmbH
InventorsFrank Schneider, Frank Jankowitsch
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Abstract
A microorganism is transformed to be capable of producing guanidinoacetic acid (GAA). A method can be used for the fermentative production of GAA using such a microorganism. A corresponding method can be used for the fermentative production of creatine.
Claims28
A microorganism, comprising:
- at least one gene coding for a protein having the function of a L-arginine:glycine amidinotransferase, and
- at least one protein having the function of a glyoxylate aminotransferase,
- wherein the at least one protein having the function of the glyoxylate aminotransferase comprises an amino acid sequence which is at least 80% homologous to an amino acid sequence selected from the group of:
- SEQ ID NO:2, SEQ ID NO:5, and SEQ ID NO:8, and
- wherein the protein having the function of the L-arginine;
- olycine amidinotransferase comprises an amino acid sequence which is at least 80% homologous to the amino acid sequence according to SEQ ID NO:
- 11.
4 more elements
Dependencies are inferred from the claim text.