Method for treatment of a leukocyte related disease by delivery of nucleic acid molecules to leukocytes using targeted lipid particles
AssigneeRamot at Tel-Aviv University Ltd.
InventorsDan Peer, Shiri Weinstein, Itai Antoine Toker, Srinivas Ramishetti
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Abstract
Disclosed are targeted lipid based particles for delivery of nucleic acid molecules (such as siRNA) to leukocytes (such as T-Cells and B-cells). Further disclosed are uses of the targeted lipid based particles for treating Leukocytes-associated diseases, such as, cancer.
Claims15
A method for treating a leukocyte associated disease, wherein the leukocyte associated disease is lymphoma, leukemia or multiple myeloma and the leukocyte is selected from a B-cell and a T-cell, comprising the step of administering to a subject in need thereof a pharmaceutical composition comprising a particle for targeted delivery of a nucleic acid to a leukocyte, the particle comprising a lipid membrane comprising a cationic lipid, a membrane stabilizing lipid and a DSPE-PEG maleimide conjugated to a targeting moiety;
- and a nucleic acid molecule encapsulated within the particle,
- wherein the targeting moiety is an antibody selected from the group consisting of an anti-CD38 antibody, an anti-CD4 antibody, an anti-CD8 antibody and an anti-CD3 antibody, or an antigen binding fragment thereof.
Dependencies are inferred from the claim text.