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US 12,065,399 B2Granted
Arylsulfonamide derivatives
AssigneeHoffmann-La Roche Inc.
InventorsBarbara Biemans, Luca Gobbi, Georg Jaeschke, Henner Knust, Lothar Lindemann, Fionn O'Hara, Jean-Marc Plancher
Life of this patent
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Abstract
The present invention provides new arylsulfonamide compounds having the general formula (I) wherein L, R1, R2, R3 and R4 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
Claims17
A compound of formula (I)
- or a pharmaceutically acceptable salt thereof,
- wherein
- L is a bond or —C≡C—;
- R1 is phenyl optionally substituted with 1 or 2 substituents independently selected from the group consisting of halogen, hydroxy, lower alkyl, lower alkoxy or haloalkyl;
- or pyridyl optionally substituted with halogen, lower alkyl, lower alkoxy or haloalkyl;
- or pyrazolyl optionally substituted with halogen, hydroxy, lower alkyl, lower alkoxy or haloalkyl;
- R2 is phenyl optionally substituted with 1 to 3 substituents selected from the group of halogen, hydroxy, lower alkyl, lower alkoxy, haloalkyl or alkoxyalkyl;
- or a heteroaryl group optionally substituted with halogen, hydroxy, lower alkyl, lower alkoxy, haloalkyl or alkoxyalkyl, wherein the heteroaryl group is selected from the group consisting of:
- and
- R3 and R4 are halogen, haloalkyl, lower alkyl or lower alkoxy.
7 more elements
Dependencies are inferred from the claim text.