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US 12,064,533 B2Granted
Synthetic hydrogel composite
AssigneeDuke University
InventorsBenjamin J. Wiley, Huayu Tong, Jiacheng Zhao
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Abstract
Cellulose-reinforced hydrogels may include a cellulose nanofiber network and an interstitial hydrogel portion within interstitial regions of the cellulose nanofiber network, the interstitial hydrogel portion comprising polyvinyl alcohol (PVA), wherein the hydrogel component has a crystallinity of 20% or greater.
Claims8
An articular cartilage implant, comprising:
- an implant body having a top bearing surface;
- an anchoring base;
- and
- a cellulose-reinforced hydrogel comprising:
- a cross-linked cellulose nanofiber network secured over the top bearing surface of the implant body;
- and
- an interstitial hydrogel portion infiltrated within interstitial regions of the cross-linked cellulose nanofiber network,
- wherein the interstitial hydrogel portion is annealed such that a crystalline content of the annealed interstitial hydrogel portion has a crystallinity of 20% or greater,
- wherein the cellulose-reinforced hydrogel comprises at least 20% by weight of water,
- wherein the cellulose-reinforced hydrogel has a tensile strength exceeding 40 MPa,
- wherein the cross-linked cellulose nanofiber network comprises bacterial cellulose (BC).
8 more elements
Dependencies are inferred from the claim text.