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US 12,064,488 B2Granted
Nitroxide containing amyloid binding agents for imaging and therapeutic uses
AssigneeThe Regents of the University of California
InventorsJohn Voss, Ruiwu Liu
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Abstract
The present invention provides methods of using nitroxide spin-labeled amyloid beta-binding compounds to image amyloid. The present invention also provides nitroxide spin-labeled amyloid beta-binding compounds.
Claims21
A method for reducing intracellular accumulation of amyloid in a cell comprising:
- contacting the cell with an effective amount of a compound, wherein the compound has the formula:
- wherein
- R1 and R2 are each independently H or a nitroxide selected from the group consisting of:
- wherein at least one of R1 and R2 is a nitroxide, and wherein the accumulation of amyloid is reduced in the cell.
1 more element
A method for reducing amyloid toxicity comprising:
- contacting the cell with an effective amount of a compound, wherein the compound has the formula:
- wherein
- R1 and R2 are each independently H or a nitroxide selected from the group consisting of:
- wherein at least one of R1 and R2 is a nitroxide, and wherein amyloid toxicity is reduced in the cell.
1 more element
A method of counteracting oxidative stress associated with the presence of amyloid in a cell comprising:
- contacting the cell with an effective amount of a compound, wherein the compound has the formula:
- wherein
- R1 and R2 are each independently H or a nitroxide selected from the group consisting of:
- wherein at least one of R1 and R2 is a nitroxide, and wherein oxidative stress is reduced or alleviated at the site of the amyloid in the cell.
1 more element
Dependencies are inferred from the claim text.