US 12,061,203 B2 · Fluorescent compound with cyanuric-hydroxide and preparation method thereof

Abstract

A fluorescent compound in accordance with exemplary embodiments of the present invention has high stability under a water-soluble condition to be easily stored for a long time and improve pH stability and can be more efficiently used for labeling and dyeing of a target material by introducing the triazine substituted with a hydroxyl group as a linker to improve the fluorescent intensity even at a low concentration as compared with the conventional structure. Further, the fluorescent compound is excellent in optical stability and exhibits stable fluorescence in long-term dyeing, and is excellent in fluorescence intensity while being not accumulated in the body, and thus, can be easily dyed and imaged in vivo even in the use of a small amount as compared with the conventional dyes to be economically used.

Claims6

Dependent claims

A fluorescent compound for labeling a biomaterial having the following Chemical Formula 1:

where X and Y are the same as or different from each other, and each independently selected from H, —SO3− and SO3H,
R1 and R2 are independently selected from C1-5 alkyl, —(CH2)mSO3−, —(CH2)mSO3H, and
R3 and R4 are independently selected from C1-5 alkyl, —(CH2)mCOOZ and
And among R1, R2, R3, and R4, only one is selected as
n is an integer of 2 to 4,
m is an integer of 2 to 4,
p is an integer of 2 to 5,
q is an integer of 2 to 5,
r is an integer of 2 to 5, and
Z is selected from H, an N-succinimidyl group, an N-hydroxysuccinimidyl group, and an N-hydroxysuccinimidyl oxy group.

7 more elements

Dependencies are inferred from the claim text.

Fluorescent compound with cyanuric-hydroxide and preparation method thereof

Life of this patent

Fluorescent compound with cyanuric-hydroxide and preparation method thereof

Life of this patent

Abstract

Claims6