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US 12,060,605 B2Granted
Compositions and methods for nucleic acid sequencing
AssigneeSingular Genomics Systems, Inc.
InventorsEli N. Glezer, Mohammad Vatankhah Varnosfaderani, Daan Witters, Vahid Karimkhani
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Abstract
Provided herein are methods and compositions for improved sequencing techniques using, for example, polymeric particles and/or three-dimensional structures.
Claims20
A composition comprising a plurality of cores surrounded by a shell polymer, wherein:
- (a) each core of the plurality of cores is surrounded by the shell polymer;
- (b) each core of the plurality of cores is formed by polymerized units of core monomers forming a core polymer;
- (c) a core polynucleotide primer is attached to the core polymer;
- (d) a target nucleic acid is hybridized to the core primer;
- (e) the shell polymer is formed by polymerized units of shell monomers;
- and
- (f) the shell polymer is not attached to a polynucleotide primer.
4 more elements
Dependencies are inferred from the claim text.