Cell-penetrating peptides and methods of use thereof
AssigneeYale University
InventorsDaniel DiMaio, Pengwei Zhang, Gabriel Monteiro Da Silva, Weiya Bai
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Abstract
In various aspects and embodiments the invention provides compositions and methods for facilitating cell penetration of a cargo molecule. In another aspect, the invention provides a method of preventing viral infection in a subject in need thereof, the method comprising providing to the subject a therapeutically effective amount of a polypeptide comprising a cell-penetrating peptide and a retromer binding site.
Claims15
A method of delivering a cargo molecule to the cytoplasm of at least one cell, the method comprising contacting the cell with a transport construct comprising the cargo molecule and at least one cell-penetrating peptide selected from SEQ ID NOs:
- 2 or 360 or a salt thereof.
A method of promoting endosomal escape for a cargo molecule, the method comprising contacting at least one cell with a transport construct comprising the cargo molecule and at least one cell-penetrating peptide selected from SEQ ID NO:
- 360, or a salt thereof.
An isolated transport construct comprising a cargo molecule and at least one cell-penetrating peptide selected from SEQ ID NOs:
- 2 or 360, or a salt thereof.
Dependencies are inferred from the claim text.