Back to results
US 12,060,337 B2Granted
Substituted dibenzo[b, f]azepines as proteasome activators
AssigneeBoard of Trustees of Michigan State University
InventorsJetze J. Tepe, Theresa A. Lansdell, Evert Njomen, Corey Lee Jones
Life of this patent
Estimating the term…
Abstract
The disclosure is directed to substituted dibenzo[b,f]azepines of the formula (II): wherein the variables n, X3, R1, R2, R4, and R5 are defined herein, and uses of such compounds to treat conditions including neurodegenerative diseases and cancers.
Claims19
A compound of formula (II):
- or a pharmaceutically acceptable salt thereof,
- wherein:
- X3 is —CH2CH2—;
- R1 is H, halo, alkyl, O(alkyl), aryl, or O(aryl);
- R2 is H, halo, alkyl, O(alkyl), aryl, or O(aryl);
- R4 is halo, alkyl, O(alkyl), or S(alkyl);
- R5 is C(O)NR6R7 or C(O)OR6;
- R6 is H, alkyl, or aryl;
- R7 is H, alkyl, or aryl;
- or
- R6 and R7, taken together with the nitrogen atom to which they are attached, form a heterocyclyl;
- and
- n is 1.
10 more elements
Dependencies are inferred from the claim text.