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US 12,060,333 B2Granted
Aminocarbamoyl compounds for the treatment of viral infections
AssigneeHoffmann-La Roche Inc.
InventorsChungen Liang, Hongying Yun, Weixing Zhang, Kun Miao, Jianguo Chen, Yao Wu
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Abstract
The present invention relates to compounds of formula (I), wherein R1-R5 and L are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.
Claims15
A compound of formula (II),
- wherein
- X is carbonyl or SO2;
- R1 is H, C1-6alkyl, C3-7cycloalkylC1-6alkyl, or (C1-6alkyl)3Si—C1-6alkyl, wherein said C3-7cycloalkyl is optionally substituted with one to two substituents independently selected from halogen and C1-6alkyl;
- R2 is C1-6alkoxy, phenylC2-6alkenyl, benzyloxy, oxazolyl, isoxazolyl, 1H-pyrrolo[2,3-b]pyridinyl, 1H-pyrrolo[3,2-c]pyridinyl, 6H-pyrrolo[2,3-c]pyridinyl, 1H-indolyl, 1H-benzimidazolyl, benzyl, imidazolyl, pyrazinyl, thiazolyl, imidazo[1,2-a]pyridine, pyrazolo[1,5-a]pyridine, phenyl-NH—C1-6alkyl;
- wherein each of said phenylC2-6alkenyl, phenyl-NH—C1-6alkyl, oxazolyl, isoxazolyl, thiazolyl, benzimidazolyl, 6H-pyrrolo[2,3-c]pyridinyl, and 1H-indolyl is unsubstituted or substituted with one to two substituents independently selected from halogen, C1-6alkyl, halo-C1-6alkyl, and C1-6alkoxy;
- R3 is H or C1-6alkyl;
- R4 is H, carbamoyl, axopyrrolidinyl, oxopiperidinyl, 1H-pyrazolyl, 1H-imidazolyl, or (C1-6 alkylamino)carbonyl;
- R5 is C1-6alkyl substituted twice with halogen;
- L is —CxH2x—, wherein x is 1, 2, 3, 4, 5, or 6;
- or a pharmaceutically acceptable salt thereof.
7 more elements
A compound selected from:
- or a stereoisomer or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.