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US 12,059,634 B2Granted
Continuous manufacturing of spray-dried powders
AssigneeDsm IP Assets B.V.
InventorsAndré Hunziker, René Lang, David Schaffner, Thomas Zwick
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Abstract
The present invention relates to a method of manufacturing spray-dried powders. During the process, a solvent is used. The process is done in a continuous manner and such that the emulsification mass ratio is low when removal of the solvent is started. Preferred solvents are isopropyl acetate and ethyl acetate. The invention also relates to a set-up to run the inventive process at industrial scale.
Claims27
A process for producing a dispersion of spray-dryable particles which encapsulate at least one fat-soluble compound, wherein the process comprises:
- (a) providing a composition that comprises water and first and second types of particles dispersed in the water, wherein each of the first and second types of particles includes:
- (i) a core which comprises at least one fat-soluble compound and at least one solvent, and
- (ii) a shell surrounding the core which comprises at least one emulsifier, and wherein
- the process further comprises:
- (b) removing the at least one solvent at least partially from the core of the first and second types of particles of the composition provided by step (a) to thereby form the dispersion of spray-dryable particles which encapsulate the at least one fat-soluble compound within the core by the shell surrounding the core, and wherein
- the first and second types of particles in the composition provided by step (a) have respectively different amounts of the at least one solvent in the core such that the amount of solvent molecules of the at least one solvent in the core of the first type of particles is greater than the amount of solvent molecules of the at least one solvent in the core of the second type of particles so as to thereby establish a bimodal particle solvent distribution of the first and second types of particles.
3 more elements
Dependencies are inferred from the claim text.