Back to results
US 12,059,503 B2Granted
Method for the manufacture of solid dosage forms
AssigneeAron H. Blaesi
InventorsAron H. Blaesi, Nannaji Saka
Life of this patent
Estimating the term…
Abstract
In this specification, a method for the manufacture of solid dosage forms is disclosed. The method includes extruding a plasticized matrix through an exit port of an extrusion channel to form one or more plasticized fibers, structuring said fibers to a three dimensional structural network by patterning on a translating or rotating stage, and solidifying the patterned structure.
Claims26
A method of manufacturing pharmaceutical solid dosage forms comprising the steps of:
- injecting at least one excipient and at least one solvent into an extrusion channel having a cross section extending along its length inside a housing;
- mixing the at least one excipient and the at least one solvent to form a plasticized matrix;
- conveying the plasticized matrix towards an exit port of the extrusion channel by applying mechanical work on the plasticized matrix;
- extruding the plasticized matrix through an exit port to form one or more plasticized fibers;
- structuring one or more plasticized fibers to a three dimensional structural network by depositing said fibers along a path defined by motion of a translating or rotating stage;
- and solidifying the deposited three dimensional structural network of one or more fibers by application of a gas flow through said network;
- wherein the three dimensional structural network of one or more fibers is used in the pharmaceutical solid dosage form.
4 more elements
A method of manufacturing pharmaceutical solid dosage forms comprising the steps of:
- injecting one or more excipients into an extrusion channel having a cross section extending along its length inside a housing, wherein at least one excipient melts upon heating;
- heating the injected one or more excipients to form a plasticized matrix;
- conveying the plasticized matrix towards an exit port of the extrusion channel by applying mechanical work on the plasticized matrix;
- extruding the plasticized matrix through an exit port to form one or more plasticized fibers;
- structuring one or more plasticized fibers to a three dimensional structural network by depositing said fibers along a path defined by motion of a translating or rotating stage;
- and solidifying the deposited three dimensional structural network of one or more fibers by application of a gas flow through said network;
- wherein the three dimensional structural network of one or more fibers is used in the pharmaceutical solid dosage form.
4 more elements
A method of manufacturing pharmaceutical solid dosage forms comprising the steps of:
- injecting at least a plasticized matrix into an extrusion channel having a cross section extending along its length inside a housing;
- conveying the plasticized matrix towards an exit port of the extrusion channel by applying mechanical work on the plasticized matrix;
- extruding the plasticized matrix through an exit port to form one or more plasticized fibers;
- structuring one or more plasticized fibers to a three dimensional structural network by depositing said fibers along a path defined by motion of a translating or rotating stage;
- and solidifying the deposited three dimensional structural network of one or more fibers by application of a gas flow through said network;
- wherein the three dimensional structural network of one or more fibers is used in the pharmaceutical solid dosage form.
3 more elements
A pharmaceutical solid dosage form comprising:
- a three dimensional fiber network structure comprising one or more fibers with average fiber thickness in the range of 1.75 μm to 2.5 mm;
- said fibers having at least one excipient through the fiber thickness;
- said fibers further comprising fiber segments separated and spaced from adjoining fiber segments by free spacings;
- wherein the dosage form is manufactured by a method comprising the steps of:
- injecting one or more excipients into an extrusion channel having a cross section extending along its length inside a housing, wherein at least one excipient melts upon heating;
- heating the injected one or more active ingredients and one or more excipients to form a plasticized matrix;
- conveying the plasticized matrix towards an exit port of the extrusion channel by applying mechanical work on the plasticized matrix;
- extruding the plasticized matrix through an exit port to form one or more plasticized fibers;
- structuring one or more plasticized fibers to a three dimensional structural network by depositing said fibers along a path defined by motion of a translating or rotating stage;
- and
- solidifying the deposited three dimensional structural network of one or more fibers by application of a gas flow through said network.
8 more elements
A pharmaceutical solid dosage form comprising:
- a three dimensional fiber network structure comprising one or more fibers with average fiber thickness in the range of 1.75 μm to 2.5 mm;
- said fibers having at least one excipient through the fiber thickness;
- said fibers further comprising fiber segments separated and spaced from adjoining fiber segments by free spacings;
- wherein the dosage form is manufactured by a method comprising the steps of:
- injecting at least one least one excipient and at least one solvent into an extrusion channel having a cross section extending along its length inside a housing;
- mixing the at least one excipient and the at least one solvent to form a plasticized matrix;
- conveying the plasticized matrix towards an exit port of the extrusion channel by applying mechanical work on the plasticized matrix;
- extruding the plasticized matrix through an exit port to form one or more plasticized fibers;
- structuring one or more plasticized fibers to a three dimensional structural network by depositing said fibers along a path defined by motion of a translating or rotating stage;
- and
- solidifying the deposited three dimensional structural network of one or more fibers by application of a gas flow through said network.
8 more elements
Dependencies are inferred from the claim text.