Medical compound
AssigneeVera Salus Ricerca S.R.L.
InventorsGiovanni Mario Pitari, Claudia Giovanna Leotta, Carmelo Drago, Giovanni Nicolosi
Life of this patent
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Abstract
Provided is a medical compound including a synthetic flavone derivative, according to the formula (I) with allotment in position C-3 of a group as shown below: wherein at least two of R2-R6 are H, and the remaining are independently selected from: H, OH, R1, OR1, NO2, NH2, NHR1, F, Cl, Br, I, where R1 is a radical.
Claims21
A medical compound comprising a synthetic flavone derivative, according to the formula (III) with allotment in position C-3 of a group as shown below:
- where X is 0,
- where L is a linker,
- where a is 1,
- where b, c, d, e each are 0 or 1,
- where Y, Z, T1, and W1 are each independently selected from:
- CH2, O, NH, C(O), NHC(O), and C(O)NH, NH GO) NH;
- where R1 is a member selected from the group consisting of:
- H,
- C1-24 alkyl or heteroalkyl,
- C1-24 alkenyl or heteroalkenyl,
- C1-24 alkynyl or heteroalkynyl, and
- an acyl residue of a fatty acid;
- wherein L is selected from the following compounds:
- LINK-
- ER L
- L1
- L2
- L3
- L4
- L5
- L6
- L7
- L8
- L9
- L11
- L12
- L13
- L14
- L15
- L16
- L17
- L18
- L19
- L20
- L21
- L22
- L23
- L24
- L25
- L26
- L27
- L28
- L29
- L30
- L31
- L32
- L33
- L34
- L35
- L36
- L37
- L38
- L39
- L40
- L41
- L42
- L43
- L44
- L45
- L46
- L47
- L48
- L49
- L50
- L51
- L52
- L53
- L54
- L55
- L56
- L57
- L58
- L59
- L60
- L61
- L62
- L63
- L64
- L65
- L66
- L67
- L68
- L69
- L70
- L71
- L72
- L73
- L74
- L75
- L76
- L77
- L78
- L79
- L80
- L81
- L82
- L83
- L84
- L85
- L86
- L87
- L88
- L89
- L90
A medical compound comprising a synthetic flavone derivative, wherein the overall structure is selected from the following structure (XII):
- where n is 1,
- R10, is a member independently, and in possible combinations, selected from the group consisting of:
- H;
- C1-24 alkyl or heteroalkyl,
- C1-24 alkenyl or heteroalkenyl,
- C1-24 alkynyl or heteroalkynyl,
- an acyl residue of a saturated/unsaturated/polyunsaturated fatty acid, of either synthetic or natural origin,
- a residue that may be selected from those residues L91, L92, and L93 shown in the table below:
A medical compound comprising a synthetic flavone derivative, wherein the compound has a structure selected from compound 2 or 5
A medical compound comprising a synthetic flavone derivative, wherein the compound has a structure selected from compound 19c, 19d, 26, 29e, or 29f:
Dependencies are inferred from the claim text.