Back to results
US 12,055,536 B2Granted
Device for detection of cellular stress
AssigneesTrustees of Boston University, Northwestern University
InventorsJi-Xin Cheng, Junjie Li, Yuying Tan, Daniela Matei, Guangyuan Zhao
Life of this patent
Estimating the term…
Abstract
Disclosed is an assay for determining resistance in a target cell or tissue to a therapy associated with cellular stress using chemical microscopy and high-throughput single cell analysis to determine functional metabolic alteration, including determining metabolic reprogramming in a target cell or tissue to a therapy associated with cellular stress, and methods of using the assays.
Claims20
An assay for determining resistance in a target cell to a therapy, the assay comprising:
- measuring glucose and glycolysis derived anabolism in the target cell;
- measuring fatty acid uptake and oxidation in the target cell;
- and
- determining a change from glucose anabolism in the target cell to fatty acid uptake and oxidation energy metabolism.
1 more element
Dependencies are inferred from the claim text.