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US 12,055,493 B2Granted
Fluorescence-based detection of protein aggregation and fiber optic-based benchtop instrument
AssigneeMassachusetts Institute of Technology
InventorsMichael Strano, Daichi Kozawa, Xun Gong, Daniel Salem, Sooyeon Cho, Freddy T. Nguyen
Life of this patent
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Abstract
A sensor can include a nanostructure in a housing configured to contact a sample.
Claims15
A sensor comprising:
- a housing including a chamber, a light port and a sample contact port, the chamber configured to contain a sensor composition;
- and
- the sensor composition including a nanostructure, the nanostructure supported in a first hydrogel, which is a tunable sensor hydrogel and configured to interact with detect a protein aggregate, the sensor composition being in contact with the light port having a collimator and in direct immersion contact with a sample contact surface adjacent to the sample contact port and a fiber optic coupled to the sensor hydrogel and also coupled to both an excitation laser and a photodetector via a detection fiber configured to detect an emission wavelength from the nanostructure.
A sensor device including a housing including a chamber, a light port having a collimator and a sample contact port;
- the chamber configured to contain a sensor composition including a nanostructure supported in a first hydrogel configured to interact with a protein aggregate, a second hydrogel between the first hydrogel and the sample contact port, wherein the second hydrogel and a fiber optic including an excitation fiber configured to provide an excitation wavelength and a detection fiber configured to detect an emission wavelength via a detection fiber configured to detect an emission wavelength from the nanostructure.
Dependencies are inferred from the claim text.