Back to results
US 12,054,745 B2Granted
SC-beta cells and compositions and methods for generating the same
AssigneePresident and Fellows of Harvard College
InventorsQuinn P. Peterson, Felicia J. Pagliuca, Douglas A. Melton, Jeffrey Robert Millman, Michael Saris Segel, Mads Gurtler
Life of this patent
Estimating the term…
Abstract
Disclosed herein are methods, compositions, kits, and agents useful for inducing β cell maturation, and isolated populations of SC-β cells for use in various applications, such as cell therapy.
Claims30
A method of treating a subject with Type 1 Diabetes, comprising the step of administering to the subject a composition comprising a plurality of clusters of cells, wherein the plurality of clusters of cells comprise a plurality of cells expressing glucagon;
- and wherein at least 20% of the cells in the plurality of clusters are non-native pancreatic β-cells that:
- (a) express INS, PDX1, NKX6.1 and one or more of the following genes:
- PC2, MNX1, or ABCC8;
- (b) exhibit an in vitro glucose-stimulated insulin secretion response when subjected to a first glucose challenge;
- and
- (c) do not express somatostatin or glucagon.
3 more elements
Dependencies are inferred from the claim text.