Viral vector production system
AssigneeOxford Biomedica (UK) Limited
InventorsDaniel Farley, Kyriacos Mitrophanous
Life of this patent
Estimating the term…
Abstract
The present invention relates to a nucleic acid sequence comprising a binding site operably linked to a nucleotide of interest, wherein the binding site is capable of interacting with an RNA-binding protein such that translation of the nucleotide of interest is repressed in a viral vector production cell.
Claims13
A nucleic acid sequence comprising an RNA-binding protein (RBP) binding site operably linked to a nucleotide of interest (NOI), wherein the RBP binding site is capable of interacting with an RBP such that translation of the NOI is repressed in a viral vector production cell, wherein the RBP is heterologous to the NOI, and wherein the RBP is tryptophan RNA-binding attenuation protein (TRAP).
Dependencies are inferred from the claim text.