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US 12,054,523 B2Granted
Compositions and related methods for modulating alkaloid production by controlling PMT promoter activation mediated by transcriptional factors ERF and Myc
AssigneeUniversity of Virginia Patent Foundation
InventorsMichael Paul Timko, Paul J Rushton, Sheng-Cheng Han, Hongbo Zhang, Marta Tatiana Bokowiec
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Abstract
Compositions and methods for modifying the production levels of alkaloids in plants are provided. Alkaloid production can be genetically controlled by modulating the transcriptional activation of PMT genes mediated by members of the ERF family and/or Myc family of transcription factors. Novel nucleotide sequences encoding the Myc family of transcription factors are also provided.
Claims10
A genetically modified tobacco plant or seed comprising a polynucleotide molecule comprising at least 95% sequence identity to SEQ ID NO:
- 3, wherein said polynucleotide molecule specifically suppresses the expression level of a gene comprising the nucleotide sequence of SEQ ID NO:
- 3, and wherein expression of said gene is down-regulated.
Dependencies are inferred from the claim text.