Amorphous mixture comprising a neutral mono- or oligosaccharide and an acidic non-carbohydrate component
AssigneeGlycom A/S
InventorsBenjámin Podányi, Pierre Chassagne, Martin Matwiejuk, Markus Jondelius Hederos
Life of this patent
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Abstract
It is provided i) an amorphous carbohydrate with improved chemical stability and/or physical features, ii) a method for producing an amorphous carbohydrate with improved chemical stability and/or physical features, and iii) a method for improving the chemical stability and/or the physical features of an amorphous carbohydrate.
Claims19
A method of preparing an amorphous mixture, comprising:
- a) preparing an aqueous solution of one or more neutral mono- or oligosaccharides,
- b) adding one or more acidic non-carbohydrate components to the aqueous solution so that the pH is not lower than −log(x/5·10−3.5) and not higher than −log(x/5·10−5.8), wherein x is the concentration of the one or more neutral mono- or oligosaccharides in said aqueous solution after step a) in w/w %,
- c) spray-drying or freeze-drying the solution obtained in step b), and
- d) obtaining the amorphous mixture comprising the one or more neutral mono- or oligosaccharides and the one or more acidic non-carbohydrate components,
- wherein the mono- or oligosaccharide is a reducing mono- or oligosaccharide and the reducing monosaccharide or the monosaccharide unit at the reducing end of the oligosaccharide is an aldose,
- wherein the stability of the one or more neutral mono- or oligosaccharides in the amorphous mixture is greater than the stability of an amorphous substance consisting of the one or more neutral mono- or oligosaccharides, and
- wherein the stability of the one or more neutral mono- or oligosaccharides in the amorphous mixture comprises reduced incidence of rearranged ulose from the one or more neutral mono- or oligosaccharides.
A method of preparing an amorphous mixture comprising one or more reducing neutral mono- or oligosaccharides and one or more acidic non-carbohydrate components, comprising mixing the one or more reducing neutral mono- or oligosaccharides with a sufficient amount of the one or more acidic components to reach a pH ranging from 3.5 to 5.8 in an aqueous solution, then spray-drying or freeze-drying the aqueous solution to obtain the amorphous mixture comprising the one or more reducing neutral mono- or oligosaccharides and the one or more acidic non-carbohydrate components,
- wherein the stability of the one or more reducing neutral mono- or oligosaccharides in the amorphous mixture is greater than the stability of an amorphous substance consisting of the one or more reducing neutral mono- or oligosaccharides, and
- wherein the stability of the one or more reducing neutral mono- or oligosaccharides in the amorphous mixture comprises reduced incidence of rearranged ulose from the one or more reducing neutral mono- or oligosaccharides.
Dependencies are inferred from the claim text.