Thiocycloheptyne derivatives and their use

A compound of Formula (I)

• wherein:
• n and m are independently 0, 1, or 2 and n+m is 2;
• X is O or NR9,
• Y is NR10,
• R1, R2, R3, R4 are independently selected from the group consisting of hydrogen, halogen O, N, P, S, C1-C24 alkyl groups, C6-C24 aryl groups, C6-C24 heteroaryl groups, C7-C24 alkylaryl groups, C7-C24 alkylheteroaryl groups, C7-C24 arylalkyl groups and C7-C24 heteroarylalkyl groups,
• wherein the O, N, P, and S are -further independently coupled to hydrogen, halogen, C1-C12 alkyl groups, C2-C12 alkenyl groups, C2-C12 alkynyl groups, C3-C12 cycloalkyl groups, C1-C12 alkoxy groups, C2-C12 alkenyloxy groups, C2-C12 alkynyloxy groups, C3-C12 cycloalkyloxy groups, the C1-C12 alkyl groups optionally being interrupted by one of more hetero-atoms selected from the group consisting of O, N, P and S,
• wherein the C1-C24 alkyl groups, C6-C24 aryl groups, C6-C24 heteroaryl groups, C7-C24 alkylaryl groups, C7-C24 alkylheteroaryl groups, C7-C24 arylalkyl groups and C7-C24 heteroarylalkyl groups are independently optionally substituted with one or more substituents independently selected from the group consisting of C1-C12 alkyl groups, C2-C12 alkenyl groups, C2-C12 alkynyl groups, C3-C12 cycloalkyl groups, C1-C12 alkoxy groups, C2-C12 alkenyloxy groups, C2-C12 alkynyloxy groups, C3-C12 cycloalkyloxy groups, halogens, amino groups, oxo groups and silyl groups,
• wherein the C1-C12 alkyl groups, C2-C12 alkenyl groups, C2-C12 alkynyl groups, C3-C12 cycloalkyl groups, C1-C12 alkoxy groups, C2-C12 alkenyloxy groups, C2-C12 alkynyloxy groups and C3-C12 cycloalkyloxy groups are optionally substituted, the C1-C12 alkyl groups, the C1-C12 alkoxy groups, the C3-C12 cycloalkyl groups and the C3-C12 cycloalkoxy groups are optionally interrupted by one of more hetero-atoms selected from the group consisting of O, N, P and S,
• wherein the silyl groups are represented by the formula (R11)3Si—,
• wherein R11 is independently selected from the group consisting of C1-C12 alkyl groups, C2-C12 alkenyl groups, C2-C12 alkynyl groups, C3-C12 cycloalkyl groups, C1-C12 alkoxy groups, C2-C12 alkenyloxy groups, C2-C12 alkynyloxy groups and C3-C12 cycloalkyloxy groups, wherein the C1-C12 alkyl groups, C2-C12 alkenyl groups, C2-C12 alkynyl groups, C3-C12 cycloalkyl groups, C1-C12 alkoxy groups, C2-C12 alkenyloxy groups, C2-C12 alkynyloxy groups and C3-C12 cycloalkyloxy groups are optionally substituted, the C1-C12 alkyl groups, the C1-C12 alkoxy groups, the C3-C12 cycloalkyl groups and the C3-C12 cycloalkoxy groups being optionally interrupted by one of more hetero-atoms selected from the group consisting of O, N, P and S;
• R5, R6, R7, R8 are independently selected from the group consisting of hydrogen, halogen, O, N, P, S, C1-C24 alkyl groups, C6-C24 aryl groups, C6-C24 heteroaryl groups, C7-C24 alkylaryl groups, C7-C24 alkylheteroaryl groups, C7-C24 arylalkyl groups and C7-C24 heteroarylalkyl groups,
• wherein the O, N, P, and S are further independently coupled to hydrogen, halogen, C1-C12 alkyl groups, C2-C12 alkenyl groups, C2-C12 alkynyl groups, C3-C12 cycloalkyl groups, C1-C12 alkoxy groups, C2-C12 alkenyloxy groups, C2-C12 alkynyloxy groups, C3-C12 cycloalkyloxy groups, the C1-C12 alkyl groups optionally being interrupted by one of more hetero-atoms selected from the group consisting of O, N, P and S,
• wherein the C1-C24 alkyl groups, C6-C24 aryl groups, C6-C24 heteroaryl groups, C7-C24 alkylaryl groups, C7-C24 alkylheteroaryl groups, C7-C24 arylalkyl groups and C7-C24 heteroarylalkyl groups are independently optionally substituted with one or more substituents independently selected from the group consisting of C1-C12 alkyl groups, C2-C12 alkenyl groups, C2-C12 alkynyl groups, C3-C12 cycloalkyl groups, C1-C12 alkoxy groups, C2-C12 alkenyloxy groups, C2-C12 alkynyloxy groups, C3-C12 cycloalkyloxy groups, halogens, amino groups, oxo groups and silyl groups,
• wherein the C1-C12 alkyl groups, C2-C12 alkenyl groups, C2-C12 alkynyl groups, C3-C12 cycloalkyl groups, C1-C12 alkoxy groups, C2-C12 alkenyloxy groups, C2-C12 alkynyloxy groups and C3-C12 cycloalkyloxy groups are optionally substituted, the C1-C12 alkyl groups, the C1-C12 alkoxy groups, the C3-C12 cycloalkyl groups and the C3-C12 cycloalkoxy groups being optionally interrupted by one of more hetero-atoms selected from the group consisting of O, N, P and S,
• wherein the silyl groups are represented by the formula (R11)3Si—,
• wherein R11 is independently selected from the group consisting of C1-C12 alkyl groups, C2-C12 alkenyl groups, C2-C12 alkynyl groups, C3-C12 cycloalkyl groups, C1-C12 alkoxy groups, C2-C12 alkenyloxy groups, C2-C12 alkynyloxy groups and C3-C12 cycloalkyloxy groups, wherein the C1-C12 alkyl groups, C2-C12 alkenyl groups, C2-C12 alkynyl groups, C3-C12 cycloalkyl groups, C1-C12 alkoxy groups, C2-C12 alkenyloxy groups, C2-C12 alkynyloxy groups and C3-C12 cycloalkyloxy groups are optionally substituted, the C1-C12 alkyl groups, the C1-C12 alkoxy groups, the C3-C12 cycloalkyl groups and the C3-C12 cycloalkoxy groups being optionally interrupted by one of more hetero-atoms selected from the group consisting of O, N, P and S;
• wherein, optionally, R1 and R7, R1 with R8, R2 with R7, R2 with R8, R3 with R5, R3 with R6, R4 with R5-, and/or R4 with R6 independently form fused ring systems;
• R9, R10 are independently selected from the group consisting of hydrogen, halogen, R12, —CH═C(R12)2, —C≡CR12, —[C(R12)2C(R12)2O]q—R12, wherein q is in the range of 1 to 200, —CN, —N3, —NCX, —XCN, —XR12, —N(R12)2, —+N(R12)3, —C(X)N(R12)2, —C(R12)2XR12, —C(X)R12, —C(X)XR12, —S(O)R12, —S(O)2R12, —S(O)OR12, —S(O)2OR12, —S(O)N(R12)2, —S(O)2N(R12)2, —OS(O)R12, —OS(O)2R12, —OS(O)OR12, —OS(O)2OR12, —P(O)(R12)(OR12), —P(O)(OR12)2, —OP(O)(OR12)2, —Si(R12)3, —XC(X)R12, —XC(X)XR12, —XC(X)N(R12)2, —N(R12)C(X)R12, —N(R12)C(X)XR12 and —N(R12)C(X)N(R12)2, wherein X is oxygen or sulphur and wherein R12 is independently selected from the group consisting of hydrogen, halogen, C1-C24 alkyl groups, C6-C24 aryl groups, C6-C24 heteroaryl groups, C7-C24 alkylaryl groups, C7-C24 alkylheteroaryl groups, C7-C24 arylalkyl groups and C7-C24 heteroarylalkyl groups.