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US 12,053,777 B2Granted
Devices and methods for detecting cancerous cells
AssigneesAcademia Sinica, National Tsing Hua University
InventorsShang-Cheng Hung, Yen-Chun Ko, Cheng-Fang Tsai, Gwo-Bin Lee, Wei-Chun Tsai
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Abstract
Disclosed herein is an integrated microfluidic chip for detecting cancerous cells, particularly, cholangio-cancerous cells, from a biological sample. Also disclosed herein is a method of detecting cholangio-cancerous cells from a biological sample.
Claims4
A method of detecting cholangio-cancerous cells from a biological sample comprising:
- contacting the biological sample with a magnetic bead pre-coated with an octasaccharide of formula (I),
- wherein,
- R1 is —NHSO3M;
- R2 and R3 are independently —SO3M;
- and
- M is a monovalent cation selected from the group consisting of sodium ion, potassium ion, lithium ion and ammonium ion;
- and
- a binding between the magnetic bead and the biological sample indicates the detection of cholangio-cancerous cells in the biological sample.
5 more elements
Dependencies are inferred from the claim text.