Amino-reactive positively charged ATRP initiators that maintain their positive charge during synthesis of biomacro-initiators
AssigneeCarnegie Mellon University
InventorsAlan J. Russell, Hironobu Murata
Life of this patent
Estimating the term…
Abstract
Provided herein are materials and methods that include utilizing atom transfer radical polymerization (ATRP) initiator molecules that maintain a positive charge during biomacro-initiator synthesis.
Claims23
A method for generating a protein-initiator conjugate, comprising contacting a protein with an controlled radical polymerization (CRP) initiator, wherein the CRP initiator comprises an amine-reactive group, one or more alkyl halide groups, and a positively charged group.
A protein-initiator conjugate comprising a protein coupled to a controlled radical polymerization (CRP) initiator, wherein the CRP initiator comprises an amine-reactive group, one or more alkyl halide groups, and a positively charged group.
A method for generating a protein-polymer conjugate, the method comprising contacting a protein-initiator conjugate with a population of monomers in the presence of a transition metal catalyst or metal-free organic complex that can participate in a redox reaction, wherein the initiator comprises an amine-reactive group, one or more alkyl halide groups, and a positively charged group.
Dependencies are inferred from the claim text.