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US 12,050,189 B2Granted
Compositions and methods relating to structural determination of small proteins
AssigneePresident and Fellows of Harvard College
InventorsXudong Wu, Tom A. Rapoport
Life of this patent
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Abstract
The technology described herein is directed to structural analysis, particularly of small proteins via cryo-EM.
Claims17
A polypeptide composition or kit comprising at least one of:
- a) a first polypeptide comprising:
- a nanobody that:
- i) specifically binds a target molecule, and
- ii) comprises a framework sequence with at least 95% sequence identity to the sequence any one of SEQ ID NOS:
- 24, 29, 34, 39, and 44;
- b) a second polypeptide comprising:
- an antibody that specifically binds the first polypeptide,
- an antigen-binding portion of an antibody that specifically binds the first polypeptide, or
- an antibody reagent that specifically binds the first polypeptide;
- and
- c) a third polypeptide comprising:
- i) at least one maltose binding protein (MBP) domain;
- ii) at least one domain of Protein A;
- and
- iii) at least one Protein G domain, Protein L domain, or Protein M domain).
12 more elements
Dependencies are inferred from the claim text.