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US 12,049,518 B2Granted
Pharmacokinetics and cholecystokinin-2 receptor (CCK2R) targeting for diagnosis and therapy
AssigneeMedizinische Universität Innsbruck
InventorsElisabeth Von Guggenberg Zu Riedhofen, Maximilian Klingler
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Abstract
The present invention provides valuable peptidomimetics for therapeutic and diagnostic purposes as well as compositions, methods, uses and kits based on these peptidomimetics. In particular, the peptidomimetics of the present invention are incorporated by CCK2R expressing cells, for instance, cancer cells. This allows, for instance, to selectively destroy cancer cells or to selectively image cancer cells that express CCK2R.
Claims23
A peptidomimetic comprising an amino acid polymer with the sequence
- DGlu-Ala-Tyr-Gly-Trp-(N-Me)Nle-Asp-1Nal-NH2,
- DGlu-Ala-Tyr-Gly-Trp-(N-Me)Nle-Asp-2Nal-NH2,
- DGlu-Pro-Tyr-Gly-Trp-(N-Me)Nle-Asp-1Nal-NH2,
- DLys-Ala-Tyr-Gly-Trp-(N-Me)Nle-Asp-1Nal-NH2,
- DGlu-Tyr-Pro-Gly-Trp-(N-Me)Nle-Asp-1Nal-NH2, or
- DGlu-Ala-Tyr-Gly-Trp-(N-Me)Nle-Asp-(N-Me)1Nal-NH2.
3 more elements
A peptidomimetic consisting of the amino acid sequence:
- DGlu-Ala-Tyr-Gly-Trp-(N-Me)Nle-Asp-1Nal-NH2.
Dependencies are inferred from the claim text.