Processes for the preparation of soluble salts of inositol phosphates
AssigneeSanifit Therapeutics S.A.
InventorsBernat Isern Amengual, Marco Antonio Moreno Santurino, Joan Perelló Bestard
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Abstract
The present invention provides processes for preparing soluble salts of inositol phosphate characterized by a low level of impurities. Processes for preparing soluble salts (e.g., alkali-metal or ammonium) of inositol phosphates (e.g., hexasodium or dodecasodium salts), and of inositol hexaphosphate in particular (e.g., Na6IP6 and Na12IP6), are described. Also provided are pharmaceutical compositions, methods of use, combination treatments, kits, and articles of manufacture comprising soluble salts of inositol phosphates prepared according to the method of the invention.
Claims30
A process for preparing a purified inositol phosphate (IP) salt, wherein the process comprises
- (A) an ion removal step comprising:
- (a) dissolving an IP salt in water to obtain an IP solution;
- (b) contacting the IP solution of step (a) with an ion exchange medium, thereby yielding an ion exchanged IP solution;
- (c) concentrating the ion exchanged IP solution of step (b) to obtain an IP syrup containing a soluble IP salt;
- and,
- (d) separating the soluble IP salt of step (c) from the IP syrup in the presence of an alkoxide;
- and,
- (B) a purification step comprising:
- (i) dissolving the soluble IP salt separated in step (d) in water to obtain an IP solution;
- (ii) converting the IP solution of step (i) to an IP suspension;
- (iii) washing the IP suspension of step (ii) with an alcohol solution to obtain an IP solid;
- and,
- (iv) drying the IP solid of step (iii) to obtain the purified IP salt.
A process for preparing a purified inositol phosphate (IP) salt, wherein the process comprises an ion removal step comprising:
- (a) dissolving an IP salt in water to obtain an IP solution;
- (b) contacting the IP solution of step (a) with an ion exchange medium, thereby yielding an ion exchanged IP solution;
- (c) concentrating the ion exchanged IP solution of step (b) to obtain an IP syrup containing a soluble IP salt;
- and,
- (d) separating the soluble IP salt of step (c) from the IP syrup in the presence of an alkoxide.
Dependencies are inferred from the claim text.