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US 12,049,460 B2Granted
EGFR inhibitor compounds
AssigneeRecurium IP Holdings, LLC
InventorsKevin Duane Bunker, Peter Qinhua Huang, Sunny Abraham, Joseph Robert Pinchman, Chad Daniel Hopkins, Deborah Helen Slee
Life of this patent
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Abstract
Disclosed herein are nitrogen-containing bicyclic compounds of Formula (I), including pharmaceutically acceptable salts thereof, together with pharmaceutical compositions and methods of ameliorating and/or treating a cancer described herein with one or more of the compounds described herein.
Claims20
A compound of Formula (I), or a pharmaceutically acceptable salt thereof, wherein Formula (I) has the structure:
- R1 is selected from hydroxy and an unsubstituted C1-4 alkoxy;
- R2
- wherein R2A is an unsubstituted bicyclo pentyl, a fluoro-substituted bicyclo pentyl, a chloro-substituted bicyclo pentyl or a cyano-substituted bicyclo pentyl;
- and wherein R2 is optionally substituted with one or more substituents independently selected from halogen, cyano, an unsubstituted C1-4 alkyl, an unsubstituted C1-4 haloalkyl, an unsubstituted C1-4 alkoxy, an alkyl substituted mono-substituted amine and an alkyl substituted di-substituted amine;
- R3 is a substituted C1-4 alkyl, wherein R3 is substituted with —(CR6AR6B)nNR7AR7B;
- X1 is NR4;
- R4 is selected from hydrogen and an unsubstituted C1-4 alkyl;
- R6A and R6B are each hydrogen;
- R7A and R7B are independently selected from hydrogen and an unsubstituted C1-4 alkyl;
- A1 is CR8;
- R8 is selected from hydrogen, fluoro, chloro and cyano;
- m is 1;
- and
- n is 0 or 1.
11 more elements
Dependencies are inferred from the claim text.