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US 12,048,779 B2Granted
Engineering mechanically functional human cartilage and method of making same
AssigneeThe Trustees of Columbia University in the City of New York
InventorsSarindr Bhumiratana, Gordana Vunjak-Novakovic
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Abstract
Medical devices having engineered mechanically functional cartilage from adult human mesenchymal stem cells and method for making same.
Claims20
A medical device comprising,
- engineered human cartilage, wherein the engineered human cartilage has a Young's modulus greater than about 400 kPa and an equilibrium friction coefficient less than about 0.4, and wherein the engineered cartilage consists essentially of:
- condensed mesenchymal bodies (CMBs);
- cartilage extracellular matrix;
- cartilage;
- subchondral bone;
- and a scaffold consisting of decellularized bone matrix.
3 more elements
A medical device comprising,
- engineered human cartilage, wherein the engineered human cartilage has a Young's modulus greater than about 400 kPa and an equilibrium friction coefficient less than about 0.4, and wherein the engineered cartilage consists essentially of:
- condensed mesenchymal bodies (CMBs);
- cartilage extracellular matrix;
- cartilage;
- and subchondral bone.
2 more elements
Dependencies are inferred from the claim text.