Methods of treating breast cancer
AssigneeBlaze Bioscience, Inc.
InventorsStacey J. Hansen, Julia E. Novak
Life of this patent
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Abstract
Compositions and formulations comprising chlorotoxin conjugate compounds are provided, including native and modified variants of chlorotoxin peptide conjugated to detectable agents or active agents. Methods of detecting and treating ductal carcinoma in situ breast cancer, invasive ductal carcinoma breast cancer, lobular carcinoma in situ, invasive lobular carcinoma, and triple-negative breast cancer with chlorotoxin conjugate compounds are also provided, including methods of imaging tumor tissues and cells.
Claims32
A method of treating a subject with breast cancer, the method comprising:
- administering a compound to the subject, wherein the compound comprises a polypeptide conjugated to a detectable agent, wherein the polypeptide has at least 80% sequence identity with SEQ ID NO:
- 9, or the polypeptide has at least 80% sequence identity with a fragment of SEQ ID NO:
- 9, wherein the fragment of SEQ ID NO:
- 9 is at least 29 amino acid residues in length;
- selectively labeling a breast cancer tissue in the subject with the compound;
- and
- performing image guided excision of the breast cancer tissue from the subject with a tumor margin of from 0.2 cm to 1 cm,
- wherein the breast cancer is a triple-negative breast cancer.
A method of imaging an organ or body region of a subject, the method comprising:
- administering to the subject a compound comprising a polypeptide conjugated to a detectable agent, wherein the polypeptide has at least 80% sequence identity with SEQ ID NO:
- 9, or the polypeptide has at least 80% sequence identity with a fragment of SEQ ID NO:
- 9, wherein the fragment of SEQ ID NO:
- 9 is at least 29 amino acid residues in length;
- imaging a breast tissue excised from the subject;
- detecting the presence or absence of the compound in a tissue or cell, wherein the presence of the compound in the tissue or cell indicates the presence of a breast cancer;
- and
- detecting a tumor margin of from 0.2 cm to 1 cm in the breast tissue excised from the subject using image guided excision,
- wherein the breast cancer is a triple-negative breast cancer.
Dependencies are inferred from the claim text.