Methods and compositions for treating musculoskeletal diseases
AssigneeSolarea Bio, Inc.
InventorsGerardo V. Toledo, Maria Juliana Soto-Giron, Jinwoo Kim, Julie E. Button, Eric Michael Schott
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Abstract
Described herein are methods and compositions for using microbial agents (probiotics) and agents that promote growth of certain microbes (prebiotics) for management (including prevention and treatment) of musculoskeletal disorders, including osteoporosis, osteopenia, Paget's disease, stunting, osteoarthritis, osteomyelitis, and delayed or non-union fractures.
Claims20
A method for dietary management of a musculoskeletal disease in a subject, the method comprising administering to the subject an effective amount of a synthetic microbial consortium comprising each of Lactobacillus brevis, Lactobacillus plantarum, Leuconostoc mesenteroides, and Pichia kudriavzevii.
A method for dietary management of a musculoskeletal disease in a postmenopausal subject, the method comprising administering to the subject at least 9×10{circumflex over ( )}10 CFUs of each of Lactobacillus brevis, Lactobacillus plantarum, Leuconostoc mesenteroides, and Pichia kudriavzevii co-formulated in a unit dose formulated for oral administration to the subject, wherein the unit dose is formulated as a medical food, wherein the unit dosage form of the medical food is an effective amount to reduce loss of bone mineral density (BMD) in the subject, and wherein the subject has, is diagnosed with, or is at risk for one or more of the group consisting of:
- osteoporosis, osteopenia, osteoarthritis, suboptimal fracture healing, osteomyelitis, Paget's disease, stunting, and delayed or non-union fractures.
Dependencies are inferred from the claim text.