Application of cyclodextrins (CDs) for remediation of perfluoroalkyl substances (PFASs)
AssigneeThe Florida International Univerisity Board of Trustees
InventorsKevin E. O'Shea, Mary Joelle Weiss-Errico
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Abstract
A system for remediation of perfluoroalkyl substances (PFASs) has a multiplicity of β-cyclodextrins (β-CDs) and/or modified β-CDs combined with a vehicle additive, and a delivery device. Modified β-CDs can contain a single amine functionality at a single primary carbon or single secondary carbon of the β-CD. The vehicle additive can be powdered activated carbon (PAC). The delivery device is a column, a pouch, a packet, or a sheet that can permit the contacting of a fluid environment with the β-CDs and vehicle additive. The system of remediation can be used for a fluid environment or for biological organisms. CD-based fluorescent sensors can detect PFASs in the environment.
Claims19
A method for remediation of perfluoroalkyl substances (PFASs) in a subject, comprising:
- providing a system for remediation of PFASs comprising a delivery device having contained therein an amine modified β-cyclodextrin (β-CD) that contains a single amine group at a single primary carbon or single secondary carbon of the β-CD by replacing a single hydroxyl group at the single primary carbon or single secondary carbon of the β-CD with an amine group;
- contacting the system for remediation of PFASs with the subject;
- and
- removing the PFAS comprising system for remediation of PFASs from the subject.
A method for remediation of perfluoroalkyl substances (PFASs) from a biological sample, comprising:
- providing a system for remediation of PFASs comprising a delivery device having contained therein at least one cyclodextrin (CD) adsorbed to a vehicle additive,
- the at least one CD comprising an amine modified β-cyclodextrin (β-CD) that contains a single amine group at a single primary carbon or single secondary carbon of the β-CD by replacing a single hydroxyl group at the single primary carbon or single secondary carbon of the β-CD with an amine group;
- contacting the system for remediation of PFASs with the biological sample;
- and
- removing the PFAS comprising system for remediation of PFASs from the biological sample.
A method for inhibiting a toxicity or damage caused by perfluoroalkyl substances (PFASs) in a subject, comprising:
- providing a system for remediation of PFASs comprising a delivery device having contained therein at least one cyclodextrin (CD) adsorbed to a vehicle additive, the vehicle additive comprising powdered activated carbon (PAC),
- the at least one CD comprising an amine modified β-cyclodextrin (β-CD) that contains a single amine group at a single primary carbon or single secondary carbon of the β-CD by replacing a single hydroxyl group at the single primary carbon or single secondary carbon of the β-CD with an amine group, and the delivery device being a column, a pouch, a packet, or a sheet;
- contacting the system for remediation of PFASs with the subject;
- and
- removing the PFAS comprising system for remediation of PFASs from the subject.
Dependencies are inferred from the claim text.