Synthetic cyclic peptides and methods of preparation and use thereof

A compound comprising 4-imidazolidinone-fused cyclic peptide, wherein the compound is a compound having the structure of

• or a derivative, prodrug, pharmaceutically acceptable salt, solvate, isomer, or tautomer thereof,
• wherein each occurrence of R1, R2, R3, R4, R5, R6, R7, R8, and R9 is independently selected from the group consisting of hydrogen, deuterium, halogen, hydroxyl, alkoxy, amino, aminoalkyl, carbonyl, carboxyl, carboxylic acid, alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, alkenyl, cycloalkenyl, heterocycloalkenyl, alkynyl, cycloalkynyl, heterocycloalkynyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, acyl, ester, urea, thiourea, thiol, thioalkyl, thioxo, sulfanyl, sulfinyl, sulfonyl, phosphino, ═O, nitrile, isonitrile, cyano, carbamate, guanidine, guanidine alkyl, amino acid, and any combination thereof;
• wherein R1 and R2 are optionally fused or joined to form a ring;
• each occurrence of Xa and Xb is independently selected from the group consisting of C, —CR10, N, P, P═O, S═O, and any combination thereof;
• wherein each occurrence of R10 is independently selected from the group consisting of hydrogen, deuterium, halogen, hydroxyl, hydroxylalkyl, alkoxy, amino, aminoalkyl, carbonyl, carboxyl, carboxylic acid, alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, alkenyl, cycloalkenyl, heterocycloalkenyl, alkynyl, cycloalkynyl, heterocycloalkynyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, arylalkenyl, heteroarylalkenyl, arylalkynyl, heteroarylalkynyl, acyl, ester, urea, thiourea, thiol, thioalkyl, thioxo, sulfanyl, sulfinyl, sulfonyl, phosphino, nitrile, isonitrile, cyano, carbamate, guanidine, guanidine alkyl, amino acid, and any combination thereof;
• m is an integer from 1 to 5;
• n is an integer from 1 to 20;
• o is an integer from 0 to 10;
• x is an integer from 0 to 10;
• y is an integer selected from the group consisting of 0 and 1;
• and
• z is an integer from 0 to 10.