Back to results
US 12,043,641 B2Granted
Minimally-invasive continuous clinical monitoring of small molecules with analytical accuracy
AssigneeTechnion Research & Development Foundation Limited
InventorsAharon Blank, Jens Anders, José Vidal Gancedo, Vega Lloveras Monserrat
Life of this patent
Estimating the term…
Abstract
A dendrimer including a ring core moiety, a paramagnetic group, a linking moiety and a branching moiety for continuously probing and quantifying an analyte is provided together with methods, kits and devices for performing sensitive, accurate and durable measurements.
Claims9
A kit, comprising:
- (a) a paramagnetic tag;
- and (b) a unit comprising an electron spin resonance spectrometer;
- wherein the paramagnetic tag has a dendritic structure, represented by the general Formula I:
- W-[B1]n0-[B2]m1-[B3]m2- . . . [Bg-]mg-1-[D]hLi-Gj
- wherein:
- W is a ring core moiety;
- D comprises a spin-trapping group;
- L is a G-linking moiety;
- G is a species selected from the group consisting:
- carbohydrate, cholesterol, urea, creatine, and an ion;
- B1, B2, B3 . . . Bg are each independently a branching moiety, wherein B1, B2, B3 . . . Bg together form a dendritic structure;
- n is an integer that equals to 2 to 6;
- g is an integer that ranges from 1 to 10, representing the number of generations of said dendritic structure;
- m is an integer that equals 1, 2, or 3 representing, in each occurrence, the ramification number of each generation;
- h is an integer that ranges from 1 to n×m1×m2× . . . mg-1, representing the total numbers of D in said dendritic structure;
- i is an integer that ranges from 1 to h, representing the total numbers of L in said dendritic structure, and
- j is an integer that ranges from 0 to i, representing the total numbers of G in said dendritic structure.
14 more elements
Dependencies are inferred from the claim text.